Jakó J, Szerafin L, Nagy P, Babicz T
Szabolcs-Szatmár-Bereg Megyei Kórház-Rendelöintézet, Nyíregyháza.
Orv Hetil. 1998 Sep 13;139(37):2187-9.
So far the authors have observed 27 cases of accumulation of malignant haematologic diseases within a family in their county. They published the first ten cases in Orvosi Hetilap in 1992. Most often the co-existence of the diseases with the highest incidence (non-Hodgkin's lymphoma, chronic lymphocytic leukaemia, acute leukaemia) was observed, in terms of relationship mostly the parent--child combination was observed. Analyzing the data of parent--child combinations (17 cases) they can notice two remarkable trends: 1. The "malignity degree" of the disease appearing in the second generation is either the same or greater than that of the disease of the first generation (the opposite of this was not experienced in any of the cases!). 2. The disease of the second generation appears mostly at a much younger age than that of the parent. Consequently, they can observe a "double acceleration": the disease tends to be more malignant nearly in the half of the second generation patients, and the disease appears in the children at a much younger age.
到目前为止，作者们在他们所在的县观察到一个家族中有27例恶性血液病聚集的病例。他们于1992年在《匈牙利医学周报》上发表了前十例病例。最常观察到的是发病率最高的几种疾病（非霍奇金淋巴瘤、慢性淋巴细胞白血病、急性白血病）同时存在，就亲属关系而言，大多观察到的是亲子组合。分析亲子组合的数据（17例），他们可以注意到两个显著趋势：1. 第二代出现的疾病的“恶性程度”与第一代疾病相同或更高（在任何病例中都未出现相反情况！）。2. 第二代疾病大多在比父母年轻得多的年龄出现。因此，他们观察到一种“双重加速”：在近一半的第二代患者中，疾病往往更具恶性，而且疾病在儿童中出现的年龄要小得多。
