Verma R S, Lubs H A
Hum Hered. 1976;26(4):315-8. doi: 10.1159/000152820.
Sequential Q and acridine orange R banding were performed on 50 normal individuals to determine those individuals with the maximum number of variants by acridine orange reverse banding. In three individuals from different families, one of the two homologs of each of pairs of acrocentric chromosomes was classified as variant. The variant present in two individuals enabled unambiguous determination of the paternal or maternal origin of all 10 acrocentric chromosomes. In the third family, the variants in the third generation were sufficient to determine the origin of homologs in 5 of 10 acrocentric chromosomes. Overall, the parental origin of 36 of 50 acrocentric chromosomes (72%) could be determined. In no case was the pattern of variants found in offsprings and parents incompatible with Mendelian inheritance.
对50名正常个体进行了连续的Q带和吖啶橙R带分析，以确定通过吖啶橙反向带分析具有最大变异数目的个体。在来自不同家族的三名个体中，每对近端着丝粒染色体的两条同源染色体之一被归类为变异型。两名个体中存在的变异使得能够明确确定所有10条近端着丝粒染色体的父系或母系来源。在第三个家族中，第三代的变异足以确定10条近端着丝粒染色体中5条同源染色体的来源。总体而言，50条近端着丝粒染色体中的36条（72%）的亲本来源可以确定。在任何情况下，后代和父母中发现的变异模式都与孟德尔遗传不相容。
