Mistríková J, Mrmusová M
Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic.
Acta Virol. 1998 Apr;42(2):79-82.
We have followed the effect of murine gammaherpesvirus strain 72 (MHV-72) infection and immunosuppression on the differential white blood cell count of Balb/c mice. In both the acute and chronic phase of infection, abnormal lymphocytes resembling human B lymphocytes infected with Epstein-Barr virus (EBV) were detected. Immunosuppression had no significant effect on the haematological changes during the infection. Some of mice, which had developed tumours as a consequence of infection, showed splenomegaly, lymphadenopathy, leukocytosis and high percentage of immature blastic forms of leukocytes.
我们追踪了鼠γ-疱疹病毒72株（MHV-72）感染和免疫抑制对Balb/c小鼠白细胞分类计数的影响。在感染的急性期和慢性期，均检测到类似于感染爱泼斯坦-巴尔病毒（EBV）的人类B淋巴细胞的异常淋巴细胞。免疫抑制对感染期间的血液学变化无显著影响。一些因感染而发生肿瘤的小鼠出现脾肿大、淋巴结病、白细胞增多以及未成熟母细胞样白细胞的高比例。
