Cohen L M, Cohen J L
Cohen Dermatopathology, Newton Centre, Massachusetts, USA.
Cutis. 1998 Sep;62(3):139-42.
Erythema multiforme (EM) is a hypersensitivity reaction that occurs mainly after exposure to certain medications or in the setting of infection, most commonly that due to herpes simplex virus. Rare cases of EM have been reported after allergic contact dermatitis due to various substances. There has been one case in the literature of EM following Rhus contact dermatitis. We report three patients who developed EM after allergic contact dermatitis due to poison ivy. In all three patients, targetoid lesions developed primarily on the palms and soles, either after a brief course of prednisone or during its taper. Two of the patients have had more than one episode of EM after poison ivy dermatitis. Although EM has been described after allergic contact dermatitis due to a variety of antigens (nickel being the most common), there is only one report in the literature of EM following Rhus contact dermatitis. Given the prevalence of allergic contact dermatitis due to poison ivy, this may be an under-reported complication.
多形红斑（EM）是一种超敏反应，主要在接触某些药物后或在感染情况下发生，最常见的是由单纯疱疹病毒引起的感染。已有因接触各种物质导致过敏性接触性皮炎后发生罕见的多形红斑病例报道。文献中有一例漆树接触性皮炎后发生多形红斑的病例。我们报告了3例因接触毒藤导致过敏性接触性皮炎后发生多形红斑的患者。在所有3例患者中，靶形皮损主要出现在手掌和脚底，要么在短期服用泼尼松后，要么在逐渐减量期间出现。其中2例患者在毒藤性皮炎后发生了不止一次多形红斑发作。虽然已有因多种抗原（最常见的是镍）导致过敏性接触性皮炎后发生多形红斑的描述，但文献中仅有一例漆树接触性皮炎后发生多形红斑的报道。鉴于毒藤引起的过敏性接触性皮炎很常见，这可能是一种报告不足的并发症。
