Chung J Y, Zhang Y, Adler B
Department of Microbiology, Monash University, Clayton, Vic., Australia.
FEMS Microbiol Lett. 1998 Sep 15;166(2):289-96. doi: 10.1111/j.1574-6968.1998.tb13903.x.
Pasteurella multocida is the aetiological agent of fowl cholera, bovine haemorrhagic septicaemia and atrophic rhinitis in pigs. Many strains of P. multocida express a capsule on their surface. However, nothing is known about the capsule biosynthetic locus in P. multocida although the capsule has been implicated as a virulence factor. The entire capsule locus of P. multocida A:1 was cloned and sequenced. The locus is divided into three regions. Region 1 comprises four ORFs which are involved in the transport of the capsule polysaccharide to the surface. Region 2 comprises five ORFs whose postulated protein products are involved in the biosynthesis of the polysaccharide capsule. Region 3 comprises two ORFs whose postulated products show similarity to proteins that are involved in the phospholipid substitution of the polysaccharide capsule.
多杀性巴氏杆菌是禽霍乱、牛出血性败血症和猪萎缩性鼻炎的病原体。多杀性巴氏杆菌的许多菌株在其表面表达一种荚膜。然而，尽管荚膜被认为是一种毒力因子，但关于多杀性巴氏杆菌中荚膜生物合成基因座的情况却一无所知。对多杀性巴氏杆菌A:1型的整个荚膜基因座进行了克隆和测序。该基因座分为三个区域。区域1包含四个开放阅读框，它们参与将荚膜多糖转运到表面。区域2包含五个开放阅读框，其推测的蛋白质产物参与多糖荚膜的生物合成。区域3包含两个开放阅读框，其推测产物与参与多糖荚膜磷脂取代的蛋白质具有相似性。
