Cell death throes.
作者信息
Cory S
机构信息
The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria 3050, Australia.
出版信息
Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12077-9. doi: 10.1073/pnas.95.21.12077.
Abstract
摘要
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Cell death throes.细胞死亡的阵痛。
Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12077-9. doi: 10.1073/pnas.95.21.12077.
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T and B leukemic cell lines exhibit different requirements for cell death: correlation between caspase activation, DFF40/DFF45 expression, DNA fragmentation and apoptosis in T cell lines but not in Burkitt's lymphoma.T和B白血病细胞系对细胞死亡表现出不同的需求：T细胞系中半胱天冬酶激活、DFF40/DFF45表达、DNA片段化与凋亡之间存在相关性，而在伯基特淋巴瘤中则不存在。
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Interaction of DNA fragmentation factor (DFF) with DNA reveals an unprecedented mechanism for nuclease inhibition and suggests that DFF can be activated in a DNA-bound state.DNA片段化因子（DFF）与DNA的相互作用揭示了一种前所未有的核酸酶抑制机制，并表明DFF可以在与DNA结合的状态下被激活。
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Functional interaction of DFF35 and DFF45 with caspase-activated DNA fragmentation nuclease DFF40.DFF35和DFF45与半胱天冬酶激活的DNA片段化核酸酶DFF40的功能相互作用。
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Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis.凋亡过程中CAD激活及DNA降解时CAD抑制剂的裂解
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The histone H1 C-terminal domain binds to the apoptotic nuclease, DNA fragmentation factor (DFF40/CAD) and stimulates DNA cleavage.组蛋白H1的C末端结构域与凋亡核酸酶——DNA片段化因子（DFF40/CAD）结合，并刺激DNA裂解。
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本文引用的文献
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Dna in chromatin of irradiated lymphoid tissues degrades in vivo into regular fragments.受辐照淋巴组织染色质中的DNA在体内会降解为规则片段。
FEBS Lett. 1976 Dec 31;72(2):271-4. doi: 10.1016/0014-5793(76)80984-2.
2
The apoptosis endonucleases: cleaning up after cell death?凋亡核酸内切酶：细胞死亡后进行清理？
Trends Cell Biol. 1994 Feb;4(2):37-41. doi: 10.1016/0962-8924(94)90002-7.
3
Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45.缺乏DNA片段化因子45的小鼠对DNA片段化和染色质浓缩的抗性
Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12480-5. doi: 10.1073/pnas.95.21.12480.
4
The Bcl-2 protein family: arbiters of cell survival.Bcl-2蛋白家族：细胞存活的仲裁者。
Science. 1998 Aug 28;281(5381):1322-6. doi: 10.1126/science.281.5381.1322.
5
Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.对小鼠半胱天冬酶8基因进行靶向破坏，可消除肿瘤坏死因子受体、Fas/Apo1和DR3诱导的细胞死亡，且在出生前是致死性的。
Immunity. 1998 Aug;9(2):267-76. doi: 10.1016/s1074-7613(00)80609-3.
6
Caspases: enemies within.半胱天冬酶：体内的敌人。
Science. 1998 Aug 28;281(5381):1312-6. doi: 10.1126/science.281.5381.1312.
7
Death receptors: signaling and modulation.死亡受体：信号传导与调节
Science. 1998 Aug 28;281(5381):1305-8. doi: 10.1126/science.281.5381.1305.
8
Differential requirement for caspase 9 in apoptotic pathways in vivo.体内凋亡途径中半胱天冬酶9的差异需求。
Cell. 1998 Aug 7;94(3):339-52. doi: 10.1016/s0092-8674(00)81477-4.
9
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9.缺乏半胱天冬酶-9的小鼠中凋亡减少及细胞色素c介导的半胱天冬酶激活
Cell. 1998 Aug 7;94(3):325-37. doi: 10.1016/s0092-8674(00)81476-2.
10
The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis.DNA片段化因子的40 kDa亚基在细胞凋亡过程中诱导DNA片段化和染色质浓缩。
Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8461-6. doi: 10.1073/pnas.95.15.8461.
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