Vaina L M, Belliveau J W, des Roziers E B, Zeffiro T A
Brain and Vision Research Laboratory, Department of Biomedical Engineering and Neurology, Boston University, 44 Cummington Street, Boston, MA 02215, USA.
Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12657-62. doi: 10.1073/pnas.95.21.12657.
We demonstrate performance-related changes in cortical and cerebellar activity. The largest learning-dependent changes were observed in the anterior lateral cerebellum, where the extent and intensity of activation correlated inversely with psychophysical performance. After learning had occurred (a few minutes), the cerebellar activation almost disappeared; however, it was restored when the subjects were presented with a novel, untrained direction of motion for which psychophysical performance also reverted to chance level. Similar reductions in the extent and intensity of brain activations in relation to learning occurred in the superior colliculus, anterior cingulate, and parts of the extrastriate cortex. The motion direction-sensitive middle temporal visual complex was a notable exception, where there was an expansion of the cortical territory activated by the trained stimulus. Together, these results indicate that the learning and representation of visual motion discrimination are mediated by different, but probably interacting, neuronal subsystems.
我们展示了与表现相关的皮质和小脑活动变化。在小脑前外侧观察到与学习相关的最大变化，其中激活的范围和强度与心理物理学表现呈负相关。学习发生后（几分钟内），小脑激活几乎消失；然而，当向受试者呈现新的、未训练的运动方向时，小脑激活恢复，此时心理物理学表现也恢复到随机水平。与学习相关的脑激活范围和强度的类似减少也发生在上丘、前扣带回和部分纹外皮层。对运动方向敏感的颞中视觉复合体是一个显著例外，在那里由训练刺激激活的皮质区域有所扩大。总之，这些结果表明视觉运动辨别能力的学习和表征是由不同但可能相互作用的神经元子系统介导的。
