McMillan D C, Scott H R, Watson W S, Preston T, Milroy R, McArdle C S
University Department of Surgery, Royal Infirmary, Glasgow, UK.
Nutr Cancer. 1998;31(2):101-5. doi: 10.1080/01635589809514687.
There is recent evidence that the inflammatory response may be important in the disproportionate loss of body cell mass in cancer patients. To examine this further, 18 male patients with lung or gastrointestinal cancer were studied over a 12-week period. In addition to weight, anthropometry, C-reactive protein (marker of the inflammatory response), albumin, and total body potassium were measured at baseline and 12 weeks. When those patients who lost total body potassium were compared with those who had not, there was a significant increase in the baseline and 12-week C-reactive protein concentrations (p < 0.05). The reduction in total body potassium was also associated with a reduction in triceps skinfold thickness (p < 0.05). There were significant correlations between the mean C-reactive protein concentration and the relative (r = -0.846, p < 0.001) and absolute (r = -0.806, p < 0.001) change in total body potassium over the follow-up period. This study demonstrates the association of a chronic inflammatory response with the rate of loss of body cell mass observed in cancer patients.
最近有证据表明，炎症反应可能在癌症患者身体细胞质量的不成比例损失中起重要作用。为了进一步研究这一点，对18名患有肺癌或胃肠道癌的男性患者进行了为期12周的研究。除了体重、人体测量学指标外，还在基线和12周时测量了C反应蛋白（炎症反应标志物）、白蛋白和全身钾含量。将那些全身钾含量降低的患者与未降低的患者进行比较时，基线和12周时的C反应蛋白浓度显著升高（p<0.05）。全身钾含量的降低还与肱三头肌皮褶厚度的降低相关（p<0.05）。在随访期间，平均C反应蛋白浓度与全身钾含量的相对变化（r=-0.846，p<0.001）和绝对变化（r=-0.806，p<0.001）之间存在显著相关性。这项研究证明了慢性炎症反应与癌症患者中观察到的身体细胞质量损失率之间的关联。
