Romanowska B, Zygulska-Mach H, Ksiezyk M
Katedry i Kliniki Okulistyki CM UJ w Krakowie.
Klin Oczna. 1998;100(4):211-6.
The purpose of this study was estimation of the results of treatment and probability of survival in patients with malignant choroidal melanoma at the age under 40 at the time of diagnosis.
110 patients were treated, including 61 women and 49 men. The follow-up time was 5-25 years, in the diagnosis several different methods were used: ophthalmoscopy, ultrasonography, transillumination, and in some cases additionally computer tomography, magnetic resonance imaging, and fluorescein angiography. All patients were also periodically tested for metastases. The following methods of treatment of melanoma were applied: xenon-arc photocoagulation (21 eyes), brachytherapy (33 eyes), combined treatment (45 eyes). In 58 patients enucleation, and in 2 exenteration were necessary.
Positive results of treatment were obtained in 48 patients (43.7%), 24 patients died because of metastases. The chance of survival was smaller in women, in cases of greatest dimension of the tumours, when the tumours were located in peripheral areas of the eye fundus, when the tumours infiltrated the optic nerve, and in epithelioid cell type of tumour.
本研究旨在评估诊断时年龄在40岁以下的脉络膜恶性黑色素瘤患者的治疗结果和生存概率。
共治疗110例患者，其中女性61例，男性49例。随访时间为5至25年，诊断时采用了几种不同的方法：检眼镜检查、超声检查、透照法，在某些情况下还额外使用了计算机断层扫描、磁共振成像和荧光素血管造影。所有患者还定期进行转移检测。采用了以下黑色素瘤治疗方法：氙弧光凝术（21只眼）、近距离放射疗法（33只眼）、联合治疗（45只眼）。58例患者需要眼球摘除术，2例需要眼眶内容剜除术。
48例患者（43.7%）治疗结果良好，24例患者因转移死亡。女性、肿瘤最大径较大、肿瘤位于眼底周边区域、肿瘤侵犯视神经以及肿瘤为上皮样细胞类型的患者生存机会较小。
