Pogrzebielski Arkadiusz, Orłowska-Heitzman Jolanta, Romanowska-Dixon Bozena
Department of Ophthalmology and Ocular Oncology, Collegium Medicum, Jagiellonian University, ul. Kopemika 38, 31-501 Krakow, Poland.
Graefes Arch Clin Exp Ophthalmol. 2006 Dec;244(12):1646-9. doi: 10.1007/s00417-006-0347-x.
This study aimed to investigate the clinical profile of young patients with uveal melanoma treated in 1995-2002 in the Department of Ophthalmology, Jagiellonian University, Krakow, Poland.
Retrospective case-control series.
Out of 800 patients with uveal melanoma treated between 1995 and 2002, there were 11 patients (1.4%) aged 20 or younger. The mean age of those patients was 17.9 (12-20, median 19) years. There were five men (45%) and six women (55%). In all cases, the tumor was unilateral. In five (45%) cases the tumor affected the right eye and in six (55%) cases the left eye. Eight (72%) patients were treated with local resection. Among these, eight patients, in two (18%) with iris or ciliary body melanoma we used adjuvant Ru-106 episcleral plaque brachytherapy (EPB). In two (18%) cases of choroidal melanoma, we performed I-125 EPB: one case ended with regression of the tumor, while the second did not respond to EPB and we had to enucleate the eye. In one (9%) case we performed enucleation as the primary treatment. The mean follow-up was 61.4 months, ranging 30-125 months. All those patients are still alive and no metastases were detected.
Uveal melanoma is a rare malignancy in children and teenagers. In the present series, it occurred in the iris in more than 50% of cases.
本研究旨在调查1995年至2002年期间在波兰克拉科夫雅盖隆大学眼科接受治疗的年轻葡萄膜黑色素瘤患者的临床特征。
回顾性病例对照系列研究。
在1995年至2002年期间接受治疗的800例葡萄膜黑色素瘤患者中，有11例（1.4%）年龄在20岁及以下。这些患者的平均年龄为17.9岁（12 - 20岁，中位数19岁）。其中男性5例（45%），女性6例（55%）。所有病例中，肿瘤均为单侧。5例（45%）肿瘤累及右眼，6例（55%）累及左眼。8例（72%）患者接受了局部切除术。其中，8例患者中，2例（18%）虹膜或睫状体黑色素瘤患者接受了辅助性钌 - 106巩膜外斑块近距离放射治疗（EPB）。在2例（18%）脉络膜黑色素瘤病例中，我们进行了碘 - 125 EPB：其中1例肿瘤消退，而另1例对EPB无反应，我们不得不摘除眼球。1例（9%）患者以眼球摘除作为初始治疗。平均随访时间为61.4个月，范围为30 - 125个月。所有这些患者均存活，未检测到转移。
葡萄膜黑色素瘤在儿童和青少年中是一种罕见的恶性肿瘤。在本系列研究中，超过50%的病例发生在虹膜。
