Mutaf M, Tasaki Y, Fujii T
Department of Plastic and Reconstructive Surgery, Nagasaki University School of Medicine, Japan.
Br J Plast Surg. 1998 Jul;51(5):393-401. doi: 10.1054/bjps.1997.0151.
In this study, the effects of controlled tissue expansion on the survival of unipedicled venous flaps were investigated in rats. In three groups of Lewis rats, a 3 x 6 cm unipedicled Lateral thoracic venous flap was studied with group 1 as control group (n = 30) without any manipulation, group 2 (n = 30) where an expander was introduced under the flap area but was not expanded and group 3 (n = 30) in which a 40 ml expander was introduced under the flap area and was expanded over a period of 10 days. Observations included gross and histological examination, reverse microangiography, reverse flow resistance and percentage of survival of flaps. Group 3 (expanded) showed more angiogenesis, a better delineation on microangiography, lower reverse flow resistance and higher survival rates as compared to group 2 (non-expanded). In the control group the survival rate of flaps was the poorest and the flaps showed higher rates of reverse flow resistance. Microangiography was not successful in the control group. In a pilot project prior to this experiment microscopic examination of the Lateral thoracic vein in 10 Lewis rats had confirmed the presence of two or three valves in this vein.
在本研究中，我们在大鼠身上研究了控制性组织扩张对单蒂静脉皮瓣存活的影响。在三组Lewis大鼠中，对一块3×6厘米的单蒂胸外侧静脉皮瓣进行了研究，第1组作为对照组（n = 30），未进行任何操作；第2组（n = 30）在皮瓣区域下方植入扩张器但未扩张；第3组（n = 30）在皮瓣区域下方植入一个40毫升的扩张器，并在10天内进行扩张。观察指标包括大体和组织学检查、逆行微血管造影、逆流阻力和皮瓣存活率。与第2组（未扩张组）相比，第3组（扩张组）显示出更多的血管生成、微血管造影上的边界更清晰、更低的逆流阻力和更高的存活率。在对照组中，皮瓣的存活率最差，且皮瓣显示出更高的逆流阻力率。对照组的微血管造影未成功。在本实验之前的一个试点项目中，对10只Lewis大鼠的胸外侧静脉进行显微镜检查，证实该静脉存在两到三个瓣膜。
