Kimber J, Mitchell D, Mathias C J
Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, National Hospital for Neurology and Neurosurgery, London, UK.
J Neurol Neurosurg Psychiatry. 1998 Oct;65(4):583-6. doi: 10.1136/jnnp.65.4.583.
The Holmes-Adie syndrome consists of unilateral or bilateral tonic pupils with near light dissociation and tendon areflexia. It is associated with autonomic disturbances affecting sudomotor and vasomotor function. Five such patients are reported on who also had a troublesome chronic dry cough, which was of unknown aetiology and was resistant to a range of treatments. The cough may be related to involvement of afferent or efferent pathways in the vagus. Chronic cough may be an accompaniment in the Holmes-Adie syndrome, like other forms of autonomic dysfunction.
霍姆斯-阿迪综合征表现为单侧或双侧强直性瞳孔伴光近反射分离及腱反射消失。它与影响汗腺分泌和血管舒缩功能的自主神经功能障碍有关。本文报告了5例此类患者,他们还伴有令人困扰的慢性干咳,病因不明且对一系列治疗均有抵抗。这种咳嗽可能与迷走神经传入或传出通路受累有关。慢性咳嗽可能是霍姆斯-阿迪综合征的一个伴随症状,如同其他形式的自主神经功能障碍一样。