Koohestani N, Chia M C, Pham N A, Tran T T, Minkin S, Wolever T M, Bruce W R
Department of Nutritional Sciences, University of Toronto, Ontario, Canada.
Carcinogenesis. 1998 Sep;19(9):1679-84. doi: 10.1093/carcin/19.9.1679.
McKeown-Eyssen (Cancer Epidemiol. Biomarkers Prevent., 3, 687-695, 1994) and Giovannucci (Cancer Causes Control, 6, 164-179, 1995), noting the striking similarity in lifestyle risk factors for colorectal cancer and insulin resistance, proposed that the hyperinsulinemia, glycemia and hypertriglyceridemia associated with insulin resistance promotes colon cancer. To compare the effect of diet on colon cancer promotion and insulin resistance in the F344 rat, we assessed the effect of fat, n-3 fatty acids and energy in pairwise comparisons on average size of aberrant crypt foci (ACF) and on glucose intolerance in the same animals in a single experiment. Diets high in fat and energy increased and diets with increased n-3 fatty acids and calorie restriction decreased both ACF growth and glucose intolerance compared with control diets. The measures of promotion of colon cancer and insulin resistance were strongly correlated (n = 98, r = 0.67, P < 0.001). In addition, both were highly correlated with daily energy intake (r = 0.62 and 0.66) and were also correlated with basal (post-prandial) insulin, glucose and triglycerides (r = 0.31-0.53, P < 0.01). We concluded that ACF growth and glucose intolerance are correlated for a wide range of diets and that increased circulating energy (glucose and triglycerides) may lead to both colon cancer promotion and insulin resistance.
麦基翁 - 艾森（《癌症流行病学、生物标志物与预防》，第3卷，第687 - 695页，1994年）和乔瓦努奇（《癌症病因与控制》，第6卷，第164 - 179页，1995年）注意到结直肠癌的生活方式风险因素与胰岛素抵抗存在显著相似性，他们提出与胰岛素抵抗相关的高胰岛素血症、血糖和高甘油三酯血症会促进结肠癌。为了比较饮食对F344大鼠结肠癌促进作用和胰岛素抵抗的影响，我们在一项单一实验中，通过两两比较评估了脂肪、n - 3脂肪酸和能量对同一组动物异常隐窝灶（ACF）平均大小以及葡萄糖耐量的影响。与对照饮食相比，高脂肪和高能量饮食会增加ACF生长和葡萄糖不耐受，而增加n - 3脂肪酸和限制热量的饮食则会降低ACF生长和葡萄糖不耐受。结肠癌促进作用指标与胰岛素抵抗指标高度相关（n = 98，r = 0.67，P < 0.001）。此外，二者均与每日能量摄入量高度相关（r = 0.62和0.66），并且也与基础（餐后）胰岛素、血糖和甘油三酯相关（r = 0.31 - 0.53，P < 0.01）。我们得出结论，在多种饮食情况下，ACF生长和葡萄糖不耐受是相关的，循环能量（葡萄糖和甘油三酯）增加可能会导致结肠癌促进作用和胰岛素抵抗。
