Mann D E, Kessel E R, Mullins D L, Lottenberg R
Department of Medicine, College of Medicine, University of Florida, Gainesville 32610, USA.
Am J Gastroenterol. 1998 Oct;93(10):1960-2. doi: 10.1111/j.1572-0241.1998.00555.x.
We present the case history of a 22-yr-old woman diagnosed with ischemic colitis associated with the use of oral contraceptives (OC). At the time of her presenting symptoms activated protein C (APC) resistance, a risk factor for thrombosis, was demonstrated. There was no laboratory evidence of inherited thrombophilia; that is, antithrombin III, protein C and protein S levels were normal and the factor V Leiden mutation was not present. The OC were discontinued and the patient's symptoms improved. Subsequent evaluation revealed that the activated protein C resistance had resolved. This case illustrates APC resistance as a potential link between OC use and its known association with ischemic colitis.
我们报告了一名22岁女性的病例史，该女性被诊断为与口服避孕药（OC）使用相关的缺血性结肠炎。在出现症状时，检测到血栓形成的危险因素——活化蛋白C（APC）抵抗。没有实验室证据表明存在遗传性易栓症；即抗凝血酶III、蛋白C和蛋白S水平正常，且不存在因子V Leiden突变。停用OC后，患者症状改善。后续评估显示活化蛋白C抵抗已消失。该病例说明了APC抵抗是OC使用与其已知的缺血性结肠炎关联之间的潜在联系。
