米非司酮引产足月产时胎儿脐动脉血流速度的测定

[Determination of fetal umbilical artery flow velocity during induction of term labor by mifepristone].

作者信息

Jiang X, Wang H, Zhang Z

机构信息

Hospital of Obstetrics and Gynecology, Shanghai Medical University.

出版信息

Zhonghua Fu Chan Ke Za Zhi. 1997 Dec;32(12):732-4.

PMID:9772437

Abstract

OBJECTIVE

To evaluate the effects of mifepristone for induction of term labor on blood supply of placenta.

METHODS

97 pregnant women (38-42 gestational weeks) were recruited, and randomly allocated into 2 groups, group 1 (n = 49) mifepristone was given orally 50 mg q12h for 2 days followed by misoprostol intravaginally (25 micrograms q12h); group 2 (n = 48), Sodium prasterone sulfate intravenous injection of 200 mg qd for 3 days followed by oxytocin intravenous infusion. Fetal umbilical artery flow velocity was determined before and 36-48 hours after treatment to observe the variation of S/D value in both groups.

RESULTS

There were no significant variations of S/D value in both groups (P > 0.05).

CONCLUSIONS

Mifipristone for induction of term labor (50 mg q12h for 2 days) is effective, and has no significant influence on the blood supply of placenta.

摘要

目的

评估米非司酮用于足月引产对胎盘血供的影响。

方法

招募97例孕周为38 - 42周的孕妇，随机分为2组。第1组（n = 49）口服米非司酮50 mg，每12小时1次，共2天，随后阴道放置米索前列醇（25微克，每12小时1次）；第2组（n = 48）静脉注射硫酸普拉睾酮钠200 mg，每日1次，共3天，随后静脉滴注缩宫素。在治疗前及治疗后36 - 48小时测定胎儿脐动脉血流速度，观察两组S/D值的变化。