Guan Z Z, Wang Y N, Xiao K Q, Dai D Y, Chen Y H, Liu J L, Sindelar P, Dallner G
Department of Pathology, Guiyang Medical College, Guizhou, China.
Neurotoxicol Teratol. 1998 Sep-Oct;20(5):537-42. doi: 10.1016/s0892-0362(97)00136-0.
Brain membrane lipid in rats were analyzed after being fed either 30 or 100 ppm fluoride for 3, 5, and 7 months. The protein content of brain with fluorosis decreased, whereas the DNA content remained stable during the entire period of investigation. After 7 months of fluoride treatment, the total brain phospholipid content decreased by 10% and 20% in the 30 and 100 ppm fluoride groups, respectively. The main species of phospholipid influenced by fluorosis were phosphatidylethanolamine, phosphatidylcholine, and phosphatidylserine. The fatty acid and aldehyde compositions of individual phospholipid classes were unchanged. No modifications could be detected in the amounts of cholesterol and dolichol. After 3 months of fluoride treatment, ubiquinone contents in brain were lower; however, at 7 months they were obviously increased in both groups of fluoride treatment. The results demonstrate that the contents of phospholipid and ubiquinone are modified in brains affected by chronic fluorosis and these changes of membrane lipids could be involved in the pathogenesis of this disease.
给大鼠分别喂食30 ppm或100 ppm氟化物3个月、5个月和7个月后，对其脑膜脂质进行分析。患氟中毒的大鼠大脑蛋白质含量降低，而在整个研究期间DNA含量保持稳定。氟化物处理7个月后，30 ppm和100 ppm氟化物组的大脑总磷脂含量分别下降了10%和20%。受氟中毒影响的主要磷脂种类为磷脂酰乙醇胺、磷脂酰胆碱和磷脂酰丝氨酸。各磷脂类别的脂肪酸和醛组成未发生变化。胆固醇和多萜醇的含量未检测到改变。氟化物处理3个月后，大脑中的泛醌含量较低；然而，在7个月时，两组氟化物处理的大鼠大脑泛醌含量均明显增加。结果表明，慢性氟中毒影响的大脑中磷脂和泛醌含量发生改变，这些膜脂质变化可能参与了该疾病的发病机制。
