Peng S H, Cui Y Y, Zhou T H
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Yao Xue Xue Bao. 1996;31(7):539-42.
The in vitro biotransformation of 6-methoxy butyl phthalide (MBP) by phenobarbital induced rat liver microsomes was investigated by GC/MS and GC/MS with TMS derivatization. Three major metabolites of MBP were identified as 3-OH-MBP, 6-OH-butyl phthalide and gamma-OH-MBP. A less polar metabolite was tentatively identified as an epoxidation product.
通过气相色谱/质谱联用仪（GC/MS）以及采用三甲基硅烷（TMS）衍生化的GC/MS，研究了苯巴比妥诱导的大鼠肝微粒体对6-甲氧基丁基苯酞（MBP）的体外生物转化。MBP的三种主要代谢产物被鉴定为3-羟基-MBP、6-羟基丁基苯酞和γ-羟基-MBP。一种极性较小的代谢产物初步被鉴定为环氧化产物。
