Peng S H, Zhou T H
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Yao Xue Xue Bao. 1996;31(12):950-4.
A GC-MS method for the investigation on the metabolism of 6-methoxy n-butyl phthalide (MBP) is described. After oral administration of MBP, the rat urine sample was collected, hydrolyzed with beta-glucuronidase, extracted and concentrated for TMS derivatization, and then analyzed by GC-MS. MBP and its six oxidative metabolites were determined in the 0-24 h rat urine sample. The mass spectra of the metabolites and their derivatives were presented and the in vivo metabolic pathway was discussed.
