Drouet A, Valance J
Service de Neurologie, H.I.A Desgenettes, Lyon.
Rev Neurol (Paris). 1998 Apr;154(3):253-6.
We report a case of benign intracranial hypertension due to chronic A-hypervitaminosis and a review of literature with 30 cases in adults and adolescents. The most prominent clinical features are: predominance of young women with normal weight and cured for acne; benign intracranial hypertension without other symptoms in half of cases; wide difference of daily doses and time of continuous intake. Prognosis for vitamin A intoxication is good, when intake of vitamin is discontinued. We reviewed five cases of benign intracranial hypertension due to retinoic acid. The mechanism of vitamin A neurotoxicity is still unknown.
我们报告了一例因慢性维生素A摄入过多导致的良性颅内高压病例，并对30例成人和青少年病例的文献进行了综述。最突出的临床特征是：以体重正常且痤疮已治愈的年轻女性为主；半数病例为无其他症状的良性颅内高压；每日剂量和持续摄入时间差异很大。停止摄入维生素后，维生素A中毒的预后良好。我们回顾了5例因维甲酸导致的良性颅内高压病例。维生素A神经毒性的机制仍不清楚。
