Gotteland M, Cruchet Muñoz S, Araya Quezada M, Espinoza Madariaga J, Brunser Tesarschü O
Unidad de Gastroenterología, Universidad de Chile, Santiago, Chile.
An Esp Pediatr. 1998 Aug;49(2):125-8.
The permeability of the intestinal mucosa to lactulose and mannitol was explored longitudinally in infants at 1, 3-4 and 11-12 months of age. This was also evaluated during the episodes of diarrhea that they suffered during follow-up.
Sugar excretion was measured by gas chromatography in five-hour urine samples.
A decrease in lactulose excretion was observed, which became significant at 11-12 months of age (p = 0.02). No changes were detected in mannitol excretion, although this showed a tendency to decrease. The lactulose/mannitol (L/M) ratio remained unchanged. During the 15 episodes of diarrhea observed in these infants during the 12 month follow-up, a considerable increase in this ratio was seen, due mainly to increased lactulose excretion.
It is hypothesized that the decrease in lactulose excretion between one and 11-12 months of age is part of the maturational process of the intestinal barrier, while diarrhea results in increased permeability due to damage to the absorptive epithelium.
纵向研究1、3 - 4和11 - 12月龄婴儿肠道黏膜对乳果糖和甘露醇的通透性。在随访期间婴儿发生腹泻时也对此进行评估。
通过气相色谱法测量五小时尿液样本中的糖排泄量。
观察到乳果糖排泄量下降，在11 - 12月龄时变得显著（p = 0.02）。甘露醇排泄量未检测到变化，尽管有下降趋势。乳果糖/甘露醇（L/M）比值保持不变。在这12个月随访期间观察到这些婴儿发生的15次腹泻中，该比值显著增加，主要是由于乳果糖排泄增加。
据推测，1至11 - 12月龄期间乳果糖排泄量的下降是肠道屏障成熟过程的一部分，而腹泻由于吸收上皮受损导致通透性增加。
