Uil J J, van Elburg R M, van Overbeek F M, Mulder C J, VanBerge-Henegouwen G P, Heymans H S
Dept. of Hepatogastroenterology, University Hospital Utrecht, The Netherlands.
Scand J Gastroenterol Suppl. 1997;223:70-8.
Functional integrity as an aspect of the mucosal barrier function of the small bowel can be estimated by the intestinal permeability for macromolecules. In the first part of this paper, an overview of intestinal permeability and its measurement is given.
In the second part of the paper our own experience with the Sugar Absorption Test using lactulose and mannitol to assess mucosal barrier function of gastric, small and large bowel, respectively, is described.
The Sugar Absorption Test is not recommended as a predictor of NSAID-related upper gastrointestinal damage nor as a marker of disease activity in inflammatory bowel diseases. The Sugar Absorption Test is very useful in screening for small intestinal disease, in assessing the response to treatment, and in predicting the prognosis, especially in coeliac disease. In our opinion, the D-xylose test is obsolete.
小肠黏膜屏障功能的一个方面即功能完整性可通过大分子的肠道通透性来评估。本文第一部分对肠道通透性及其测量方法进行了概述。
本文第二部分描述了我们自身使用乳果糖和甘露醇分别评估胃、小肠和大肠黏膜屏障功能的糖吸收试验的经验。
不推荐将糖吸收试验作为非甾体抗炎药相关上消化道损伤的预测指标，也不推荐将其作为炎症性肠病疾病活动的标志物。糖吸收试验在筛查小肠疾病、评估治疗反应以及预测预后方面非常有用，尤其是在乳糜泻中。我们认为，D-木糖试验已过时。
