Campanini M, Lunati F, Zigrossi P, Monteverde A
II Divisione di Medicina Generale, Azienda Ospedaliera Maggiore della Carità di Novara.
Ann Ital Med Int. 1997 Oct-Dec;12(4):223-9.
The centralization of body fat, particularly in abdominal or visceral depots, is associated with qualitative and quantitative lipid abnormalities. Examples of these qualitative alterations include changes in low density lipoprotein composition, namely an increased number of small or dense low density lipoprotein particles, which seem to be prone to increased lipid oxidation. Oxidative modification of low density lipoproteins is involved in atherosclerotic development of the arterial wall. Alterations of lipid composition often arise in a context of insulin resistance with hyperinsulinism. Genetic features, such as apolipoprotein E polymorphism, also play a significant role in lipoprotein metabolism. The principle treatment of obesity and associated dyslipidemia is to reduce energy intake through diet. Moderate exercise is effective, especially in patients with insulin resistance. Drug therapy is considered primarily for patients who refuse to make behavioral changes.
身体脂肪的集中，尤其是腹部或内脏脂肪堆积，与脂质的质和量的异常有关。这些质的改变的例子包括低密度脂蛋白组成的变化，即小而密的低密度脂蛋白颗粒数量增加，这些颗粒似乎更容易发生脂质氧化增加。低密度脂蛋白的氧化修饰参与动脉壁的动脉粥样硬化发展。脂质组成的改变通常发生在胰岛素抵抗伴高胰岛素血症的情况下。遗传特征，如载脂蛋白E多态性，在脂蛋白代谢中也起重要作用。肥胖及相关血脂异常的主要治疗方法是通过饮食减少能量摄入。适度运动是有效的，尤其是对胰岛素抵抗患者。药物治疗主要考虑用于拒绝做出行为改变的患者。
