Friedrich M, Rafi L, Tilgen W, Schmidt W, Reichrath J
Department of Gynecology, University of the Saarland, Homburg, Germany.
J Histochem Cytochem. 1998 Nov;46(11):1335-7. doi: 10.1177/002215549804601114.
We investigated immunohistochemically the expression of 1,25 dihydroxy vitamin D3 receptors (VDRs) in normal human breast tissue and in breast carcinomas. For the first time, a VDR immunoreactivity score (VDR-IRS) in breast tissue is presented. Mean VDR-IRS in breast carcinomas was 7.28 compared to 1.55 in normal breast tissue. Comparing staining patterns for VDR and Ki-67, no visual correlation was found, indicating that VDR upregulation in breast carcinomas is not exclusively controlled by the proliferative activity of these tumor cells. Our study adds to the body of evidence that breast tissue may be a sensitive target organ for therapeutically applied new vitamin D analogues that exert few calcemic side effects.
我们采用免疫组织化学方法研究了1,25-二羟维生素D3受体（VDRs）在正常人类乳腺组织和乳腺癌组织中的表达情况。首次提出了乳腺组织中的VDR免疫反应评分（VDR-IRS）。乳腺癌组织中的平均VDR-IRS为7.28，而正常乳腺组织中的为1.55。比较VDR和Ki-67的染色模式，未发现明显相关性，这表明乳腺癌中VDR的上调并非完全由这些肿瘤细胞的增殖活性所控制。我们的研究进一步证明，乳腺组织可能是治疗性应用的新型维生素D类似物的敏感靶器官，这些类似物几乎没有高钙血症副作用。
