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[职业性镉暴露与肾癌。关于一例病例]

[Occupational exposure to cadmium and renal cancer. Apropos of a case].

作者信息

Series C, Ghorayeb I, Guez S, Verdun Esquerre C, Brochard P, Poussin A, Lafitte J Y, Pomies F

机构信息

Service de médecine interne, hôpital Pellegrin-Tripode, Bordeaux, France.

出版信息

Rev Med Interne. 1998 Feb;19(2):131-3. doi: 10.1016/s0248-8663(97)83424-8.

Abstract

INTRODUCTION

Cadmium is a carcinogenic substance and bronchial and prostatic cancer may be readily identified as professional diseases. It is also a nephrotoxic substance but renal carcinoma are rarely imputed to this kind of intoxication.

CASE REPORT

We report the observation of a 59-year-old woman with a long unprotected professional exposure to cadmium. She developed an epidermoid carcinoma of the kidney and later of the lung. Levels of cadmium in blood samples were abnormally high, confirming the existence of a chronic impregnation.

CONCLUSION

We have judged cadmium to be responsible for her renal disease: the fact of a long unprotected professional exposure, the scarcity of renal epidermoid carcinoma, the well established nephrotoxicity of this substance and the association with other cancers, appear to us as convincing evidence, and the kidney cancer of our patient has been considered a professional disease.

摘要

引言

镉是一种致癌物质,支气管癌和前列腺癌很容易被认定为职业病。它也是一种肾毒性物质,但肾癌很少被归咎于这种中毒情况。

病例报告

我们报告了一名59岁女性的病例,她长期在无防护的情况下从事接触镉的职业。她患上了肾表皮样癌,后来又患上了肺癌。血液样本中的镉含量异常高,证实存在慢性镉蓄积。

结论

我们判定镉是导致她肾病的原因:长期无防护的职业接触、肾表皮样癌的罕见性、该物质已明确的肾毒性以及与其他癌症的关联,在我们看来都是令人信服的证据,我们患者的肾癌已被认定为职业病。

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