Katchourine I, Pradalier A
Service de médecine interne et centre d'allergie de l'Ouest parisien, hôpital Louis-Mourier, Colombes, France.
Rev Med Interne. 1998 Mar;19(3):185-91. doi: 10.1016/s0248-8663(97)80718-7.
Total immunoglobulin E levels are very frequently measured, particularly for allergy. Their high levels are ordinarily found in atopy and parasitosis. This article subject is to determine rare diseases where high levels of total immunoglobulin E are found except in classic diseases. These rare hyper-immunoglobulin E syndromes are more often associated with immunologic deficiency more or less intense that lead to viral, fungal and bacterial infections. Buckley syndrome: deep infections due to Staphylococcus aureus, chronic dermatitis. Netherton disease: cutaneous and hair disease, allergic manifestations. Wiskott-Aldrich syndrome: thrombocytopeny and -pathy, dermatitis. Di-George disease: hypoparathyroidism, infections. Selective deficit of immunoglobulin A: recurrent infections. It is difficult to differentiate between atopic dermatitis and Buckley syndrome and Netherton disease because of eczematiform chronic dermatitis and high-levels of total immunoglobulin E found in all these diseases.
总免疫球蛋白E水平的检测非常频繁，尤其是在过敏方面。其高水平通常见于特应性疾病和寄生虫病。本文的主题是确定除经典疾病外总免疫球蛋白E水平升高的罕见疾病。这些罕见的高免疫球蛋白E综合征更常与程度不同的免疫缺陷相关，进而导致病毒、真菌和细菌感染。巴克利综合征：由金黄色葡萄球菌引起的深部感染、慢性皮炎。内瑟顿病：皮肤和毛发疾病、过敏表现。维斯科特-奥尔德里奇综合征：血小板减少症和血小板病、皮炎。迪格奥尔格综合征：甲状旁腺功能减退、感染。免疫球蛋白A选择性缺陷：反复感染。由于所有这些疾病中均存在湿疹样慢性皮炎和总免疫球蛋白E水平升高，因此很难区分特应性皮炎与巴克利综合征和内瑟顿病。
