Devilliers H, Turcu A, Vernier N, Muller G, Bielefeld P, Bonniaud P, Besancenot J-F
Service de médecine interne et maladies systémiques, CHU François-Mitterrand, 14, rue Paul-Gaffarel, BP 77908, 21079 Dijon cedex, France.
Service de médecine interne et maladies systémiques, CHU François-Mitterrand, 14, rue Paul-Gaffarel, BP 77908, 21079 Dijon cedex, France.
Rev Med Interne. 2018 May;39(5):332-338. doi: 10.1016/j.revmed.2017.12.009. Epub 2018 Feb 4.
Hyper-IgE may be found under many pathological conditions. The role of IgE is essentially associated with the occurrence of allergic manifestations, which may be accompanied by an increase of their serum levels. Elevation of total IgE has also been reported in association with certain rare genetic immune deficiencies called hyper-IgE syndromes. Other circumstances such as infectious diseases, tumors or autoimmune diseases may also be accompanied by an excessive synthesis of IgE. Considering the diversity of these situations, discussion of the prognostic value of total IgE is useful to the internist.
高IgE可见于多种病理状况。IgE的作用本质上与过敏表现的发生相关，过敏表现可能伴有血清水平升高。总IgE升高也与某些罕见的遗传性免疫缺陷即高IgE综合征有关。其他情况如传染病、肿瘤或自身免疫性疾病也可能伴有IgE的过度合成。考虑到这些情况的多样性，讨论总IgE的预后价值对内科医生是有用的。
