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[使用防水气雾剂后发生急性肺泡炎:附2例报告]

[Acute alveolitis after using a waterproofing aerosol: apropos of 2 cases].

作者信息

Testud F, Gabrielle L, Paquin M L, Descotes J

机构信息

Centre antipoisons, Hôpital Edouard-Herriot, Lyon, France.

出版信息

Rev Med Interne. 1998 Apr;19(4):262-4. doi: 10.1016/s0248-8663(97)89328-9.

Abstract

INTRODUCTION

Waterproofing sprays for leather clothing have seldom been involved in severe accidents. In some circumstances, their pulmonary toxicity is marked, as shown by two case reports and a review of the literature.

EXEGESIS

Acute alveolitis is described in two young adults without previous respiratory illness, following the use of a waterproofing spray for leather clothing. Clinical features typical of a flu-like reaction (malaise, fever and chills) were associated with dyspnea and with hemoptysis in one patient. X-ray examination evidenced lesional edema which quickly resolved after symptomatic treatment. The toxic mechanism is debated, but experimental data and clinical findings suggest the causative role of recently introduced fluoropolymers.

CONCLUSIONS

Waterproofing sprays for leather clothing may induce severe respiratory illness after massive inhalation in confined area. Treatment is supportive.

摘要

引言

用于皮革衣物的防水喷雾很少引发严重事故。在某些情况下,其肺部毒性较为显著,两篇病例报告及文献综述表明了这一点。

释义

两名此前无呼吸系统疾病的年轻人在使用皮革衣物防水喷雾后出现急性肺泡炎。一名患者出现类似流感反应的典型临床特征(不适、发热和寒战),同时伴有呼吸困难和咯血。X线检查显示有损伤性水肿,对症治疗后迅速消退。毒性机制存在争议,但实验数据和临床发现提示了新引入的含氟聚合物的致病作用。

结论

在密闭空间大量吸入用于皮革衣物的防水喷雾可能会引发严重的呼吸系统疾病。治疗以支持治疗为主。

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