Barcat D, Constans J, Seigneur M, Guérin V, Conri C
Service de médecine interne et pathologie vasculaire, Hôpital Saint-André, Bordeaux, France.
Rev Med Interne. 1998 Jul;19(7):509-11. doi: 10.1016/s0248-8663(99)80008-3.
Some viral infections are associated with deep venous thrombosis. We report a case of deep venous thrombosis in an adult with varicella. He had neither known predisposing factors for thrombosis nor thrombophilia.
Transient significant level of antiphospholipid antibodies and lupus circulating anticoagulant were observed. There was no evidence of thrombophilia. Deep venous thrombosis has been mostly associated with varicella in children. A transient protein S deficiency was present in almost all cases, though it was sometimes related to an anti-protein S antibody. This association is exceptional in adults. Some viruses such as herpesvirus and HIV are responsible for endothelium dysfunction, but this is still unclear in the case of varicella-zoster virus.
In our observation, endothelium activation or antiphospholipid antibodies might be responsible for thrombosis.
一些病毒感染与深静脉血栓形成有关。我们报告一例成人水痘患者发生深静脉血栓形成的病例。他既无已知的血栓形成易感因素，也无血栓形成倾向。
观察到抗磷脂抗体和狼疮抗凝物出现短暂的显著水平。无血栓形成倾向的证据。深静脉血栓形成在儿童中大多与水痘有关。几乎所有病例均存在短暂的蛋白S缺乏，尽管有时与抗蛋白S抗体有关。这种关联在成人中较为罕见。一些病毒如疱疹病毒和HIV可导致内皮功能障碍，但水痘带状疱疹病毒的情况仍不清楚。
在我们的观察中，内皮激活或抗磷脂抗体可能是血栓形成的原因。
