疫苗接种以及免疫调节剂“卡介苗、阿弗立定和痤疮丙酸杆菌”对小鼠狂犬病的影响。
Effect of vaccination and the immunomodulators "bacillus of Calmette-Guérin, avridine and Propionibacterium acnes" on rabies in mice.
作者信息
Megid J, Peraçolli M T, Curi P R, Zanetti C R, Cabrera W H, Vassao R, Ito F H
机构信息
Department of Veterinary Hygiene and Public Health, FMVZ-UNESP, Botucatu-SP, Brazil.
出版信息
Comp Immunol Microbiol Infect Dis. 1998 Oct;21(4):305-18. doi: 10.1016/s0147-9571(98)00005-8.
Responses of vaccination and treatment to immunomodulators against rabies in mice were evaluated through macrophage inhibition factor (MIF), intra-pad inoculation (IPI) and serum neutralization (SN) tests and by the detection of gamma-interferon (IFN-gamma). Onco-BCG, Avridine and Propionibacterium acnes were administered to groups of mice. Higher survival rates were found in animals treated with P. acnes. Lower levels of IFN-gamma were observed in the groups of infected and vaccinated mice. The IPI was not effective on detecting the response of delayed-type hypersensitivity. Vaccine induced in the infected animals a more intense response to MIF reaction.
通过巨噬细胞抑制因子（MIF）、足垫接种（IPI）和血清中和（SN）试验以及检测γ-干扰素（IFN-γ），评估了小鼠体内针对狂犬病的疫苗接种和免疫调节剂治疗的反应。将瘤苗卡介苗、阿佛立定和痤疮丙酸杆菌分别给予几组小鼠。结果发现，用痤疮丙酸杆菌治疗的动物存活率更高。在感染和接种疫苗的小鼠组中观察到较低水平的IFN-γ。IPI在检测迟发型超敏反应方面无效。疫苗在感染动物中诱导了对MIF反应更强烈的反应。
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