Côrtes J A, Rweyemamu M M, Ito F H, Umehara O, Medeiros Neto R R, De Lucca-Neto D, Baltazar M C, Vasconcellos S A, Vasconcellos M E
Departamento de Medicina Veterinária Preventiva e Saúde Animal, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Brazil.
Rev Sci Tech. 1993 Sep;12(3):941-55. doi: 10.20506/rst.12.3.726.
In a comparative study of two commercial baby hamster kidney rabies vaccines produced in Brazil, the authors were able to demonstrate the following: a) both vaccines provoked a high level of antibody response and protection against challenge in cattle b) in primary vaccination, at least, the addition of avridine (a synthetic lipoidal amine) enhances the immune response in terms of the level and persistence of antibody c) over 90% of cattle vaccinated with either vaccine were protected against experimental challenge one year after revaccination, and the antibody response profile indicated that these vaccines were capable of maintaining antibody titres above protective levels for more than two years after revaccination. On the basis of these results, the authors recommend optional revaccination of young animals (i.e. "primo-vaccinates") at six months of age. Thereafter, annual revaccination should be sufficient to ensure high levels of antibody between vaccination cycles.
在一项对巴西生产的两种商业性幼仓鼠肾狂犬病疫苗的比较研究中，作者能够证明以下几点：a) 两种疫苗均能引发高水平的抗体反应，并对牛起到攻毒保护作用；b) 至少在初次接种时，添加阿夫立定（一种合成类脂胺）可在抗体水平和持久性方面增强免疫反应；c) 再次接种一年后，接种任一种疫苗的牛超过90%受到实验性攻毒保护，抗体反应情况表明，这些疫苗在再次接种后两年多时间内能够使抗体滴度维持在保护水平以上。基于这些结果，作者建议对幼龄动物（即“初免动物”）在6月龄时进行选择性再次接种。此后，每年再次接种应足以确保在接种周期之间维持高水平抗体。
