Frances S P, Cooper R D, Sweeney A W
Australian Army Malaria Institute, Enoggera, Queensland, Australia.
J Med Entomol. 1998 Sep;35(5):690-3. doi: 10.1093/jmedent/35.5.690.
Laboratory and field tests of the repellents diethyl methylbenzamide (deet), 1-(3-cyclohexen-1-yl-carbonyl)-2-methylpiperidine (AI3-37220), and (2-hydroxymethylcyclohexyl) acetic acid lactone (CIC-4) were conducted against Anopheles farauti s.s. Laveran, an important malaria vector in the southwest Pacific region. In the laboratory, An. farauti was tolerant of all 3 repellents, but deet and CIC-4 provided significantly better protection than AI3-37220. The field study was conducted in rain forest located near Innisfail, northern Queensland, and tested 25% (vol:vol) ethanol solutions of each repellent against An. farauti. All 3 repellents provided > 95% protection against An. farauti for 5 h after application. In contrast to the laboratory tests, protection provided by AI3-37220 was significantly better than that by either deet or CIC-4, and there was no difference between protection by deet and CIC-4. The protection by deet and CIC-4 declined 8 h after application and provided < or = 50% protection at 9 h. In contrast, AI3-37220 provided > or = 94% protection for 9 h.
针对太平洋西南部地区重要的疟疾传播媒介——法氏按蚊指名亚种（Anopheles farauti s.s. Laveran），开展了驱蚊剂二乙甲苯酰胺（避蚊胺）、1-(3-环己烯-1-基羰基)-2-甲基哌啶（AI3-37220）和（2-羟甲基环己基）乙酸内酯（CIC-4）的实验室和现场测试。在实验室中，法氏按蚊对所有这三种驱蚊剂都有耐受性，但避蚊胺和CIC-4提供的防护明显优于AI3-37220。现场研究在昆士兰州北部因尼斯费尔附近的雨林中进行，测试了每种驱蚊剂的25%（体积比）乙醇溶液对法氏按蚊的效果。所有这三种驱蚊剂在施用后5小时内对法氏按蚊的防护率均超过95%。与实验室测试不同的是，AI3-37220提供的防护明显优于避蚊胺或CIC-4，避蚊胺和CIC-4提供的防护之间没有差异。避蚊胺和CIC-4在施用8小时后防护效果下降，在9小时时防护率≤50%。相比之下，AI3-37220在9小时内提供的防护率≥94%。
