Coleman R E, Robert L L, Roberts L W, Glass J A, Seeley D C, Laughinghouse A, Perkins P V, Wirtz R A
Department of Entomology, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
J Med Entomol. 1993 May;30(3):499-502. doi: 10.1093/jmedent/30.3.499.
Deet, the lactone CIC-4, and the piperidine compounds A13-37220 and A13-35765 were evaluated for initial repellency against laboratory-reared Anopheles albimanus Wiedemann, An. freeborni Aitken, An. gambiae Giles, An. stephensi Liston, and Phlebotomus papatasi (Scopoli) using a dose-response testing procedure on human volunteers. In addition, deet and CIC-4 were tested against Lutzomyia longipalpis (Lutz & Neiva). In general, the repellency of A13-37220, A13-35765, and CIC-4 was not markedly different from that of deet against each species tested; however, the different species varied greatly in response to the repellents. Overall, An. stephensi, L. longipalpis, and P. papatasi were the most sensitive, and An. albimanus the most tolerant species. The four repellents subsequently were tested against An. stephensi and An. albimanus to determine the duration of repellency. AI3-37220 provided effective (> 90%) protection against An. stephensi bites for 7 h, whereas deet, AI3-35765, and CIC-4 provided 6, 5, and 3 h of protection, respectively. Each of the four compounds provided < 1 h of protection against An. albimanus bites.
使用剂量反应测试程序，在人类志愿者身上评估了避蚊胺、内酯CIC - 4以及哌啶化合物A13 - 37220和A13 - 35765对实验室饲养的白纹伊蚊、弗里伯恩按蚊、冈比亚按蚊、斯氏按蚊和巴氏白蛉的初始驱避效果。此外，还对避蚊胺和CIC - 4进行了针对长须罗蛉的测试。总体而言，A13 - 37220、A13 - 35765和CIC - 4对所测试的每种蚊虫的驱避效果与避蚊胺相比并无显著差异；然而，不同蚊虫对这些驱避剂的反应差异很大。总体来说，斯氏按蚊、长须罗蛉和巴氏白蛉最为敏感，而白纹伊蚊最具耐受性。随后对这四种驱避剂进行了针对斯氏按蚊和白纹伊蚊的测试，以确定驱避持续时间。A13 - 37220对斯氏按蚊叮咬提供了7小时的有效（>90%）防护，而避蚊胺、A13 - 35765和CIC - 4分别提供了6小时、5小时和3小时的防护。这四种化合物对白纹伊蚊叮咬的防护时间均不足1小时。
