Olin P, Giesecke J
Department of Vaccine Research, Swedish Institute for Infectious Disease Control, and the Karolinska Institute, Stockholm.
Dev Biol Stand. 1998;94:227-33.
U.S. polio vaccines produced during the 1950s were potentially contaminated by simian virus 40 (SV40). Recently DNA from SV40 has been detected in brain ependymoma, pleural mesothelioma and osteosarcoma. In 1957, when national polio vaccination was started in Sweden, vaccine potentially contaminated with SV40 was given to approximately 700,000 individuals, mainly pre-school and school children born between 1946 and 1953. From 1958, a Swedish inactivated polio vaccine was exclusively used, which has been claimed to be free of SV40. We explored cancer incidence rates in the cohorts exposed to the potentially contaminated polio vaccines in Sweden. The Swedish Cancer Registry provided annual cancer incidence rates in five-year age groups for the years 1960-93. Cancer incidence in cohorts maximally exposed was followed during this period, and the incidence when these cohorts reached a specific age was compared to the incidence when unexposed cohorts reached the same age. For osteosarcoma and brain ependymoma overall age-standardised incidence rates were essentially unchanged between 1960 and 1993, and age specific rates were similar in the exposed and unexposed male and female cohorts. During the same period, overall age standardised incidence rates in males of brain cancers increased from 9.0 to 13.1 and of pleural mesotheliomas from 0.2 to 2.1 per 100,000. None of these increased rates was associated with the exposed cohorts. The use of potentially SV40 contaminated inactivated polio vaccines in Sweden has not been shown to be associated with increased cancer incidence. However, the exposed cohorts have not yet reached the age of increased risk of brain cancer or mesothelioma.
20世纪50年代生产的美国脊髓灰质炎疫苗可能被猴病毒40（SV40）污染。最近，在脑室管膜瘤、胸膜间皮瘤和骨肉瘤中检测到了SV40的DNA。1957年瑞典开始全国脊髓灰质炎疫苗接种时，约70万人接种了可能被SV40污染的疫苗，主要是1946年至1953年出生的学龄前儿童和学童。从1958年起，瑞典专门使用了一种灭活脊髓灰质炎疫苗，据称该疫苗不含SV40。我们研究了瑞典接触过可能被污染的脊髓灰质炎疫苗的队列中的癌症发病率。瑞典癌症登记处提供了1960 - 1993年按五岁年龄组划分的年度癌症发病率。在此期间，对暴露程度最高的队列中的癌症发病率进行了跟踪，并将这些队列达到特定年龄时的发病率与未暴露队列达到相同年龄时的发病率进行了比较。对于骨肉瘤和脑室管膜瘤，1960年至1993年期间总体年龄标准化发病率基本没有变化，暴露组和未暴露组的男性和女性年龄别发病率相似。在同一时期，男性脑癌的总体年龄标准化发病率从每10万人中的9.0例增加到13.1例，胸膜间皮瘤从每10万人中的0.2例增加到2.1例。这些发病率的增加均与暴露队列无关。在瑞典使用可能被SV40污染的灭活脊髓灰质炎疫苗尚未显示与癌症发病率增加有关。然而，暴露队列尚未达到患脑癌或间皮瘤风险增加的年龄。
