Sarić Marko, Curin Katja, Varnai Veda M
Institute for Medical Research and Occupational Health, Zagreb, Croatia.
Coll Antropol. 2008 Jun;32(2):479-83.
From the Croatian Cancer Registry (period 1991-1997) 194 malignant pleural mesothelioma patients were collected. According to participation in polio vaccination mass campaign in 1961 that covered the entire Croatian population aged 3 months to 20 years, mesothelioma patients were divided in vaccinated (N=58), and non-vaccinated (N=136) subjects. Significantly higher percentage of those with a history of occupational exposure to asbestos was found in vaccinated (79%) compared to non-vaccinated group (63%). This is the opposite to what would be expected if potential SV40 contamination of polio vaccine used had a causative role in the development of the tumour. On the other hand, shorter latency period reflected by very high percentage of 45-year-old or younger mesothelioma patients in vaccinated group (15 out of 58), with all of them having a history of occupational asbestos exposure, raises a question for a possible enhancing effect of the vaccine used to asbestos exposure, if it was contaminated with SV40.
从克罗地亚癌症登记处（1991 - 1997年期间）收集了194例恶性胸膜间皮瘤患者。根据1961年覆盖整个克罗地亚3个月至20岁人群的脊髓灰质炎疫苗大规模接种情况，间皮瘤患者被分为接种疫苗组（N = 58）和未接种疫苗组（N = 136）。与未接种疫苗组（63%）相比，接种疫苗组中有职业性石棉接触史的患者比例显著更高（79%）。如果所使用的脊髓灰质炎疫苗存在潜在的SV40污染在肿瘤发生中起致病作用，那么情况应该相反。另一方面，接种疫苗组中45岁及以下间皮瘤患者的比例非常高（58例中有15例），这反映出潜伏期较短，且他们都有职业性石棉接触史，这就引发了一个问题：如果疫苗被SV40污染，那么所使用的疫苗是否可能对石棉接触有增强作用。
