Anderson J T, Dehner L P
J Bone Joint Surg Am. 1976 Oct;58(7):994-1000.
Of fourteen patients with Paget's disease for whom adequate roentgenograms and pathological material were available, six had lesions showing significant or predominant osteolysis. Based on a study of these six patients and a review of the literature, the following mechanisms were identified as causes of the so-called osteolytic type of the disease: (1) an "early" destructive Paget's lesion; (2) "advanced" Paget's disease with secondary degenerative changes; (3) "seeding" of an independent osteolytic lesion, particularly tumor in pre-existing Paget's disease; (4) sarcomatous transformation; and (5) immobilization after fracture. An osteolytic lesion in a patient without other bone disease may be due to Paget's disease, while an associated lytic lesion may be the result of a variety of conditions. Accurate pathological diagnosis is essential.
在14例有足够X线片和病理材料的佩吉特病患者中，6例有显示明显或主要骨质溶解的病变。基于对这6例患者的研究及文献回顾，以下机制被确定为所谓溶骨型该疾病的病因：（1）“早期”破坏性佩吉特病变；（2）伴有继发性退行性改变的“晚期”佩吉特病；（3）独立溶骨病变的“播散”，特别是在已有佩吉特病基础上的肿瘤；（4）肉瘤变；（5）骨折后制动。无其他骨病患者的溶骨病变可能归因于佩吉特病，而相关的溶骨性病变可能是多种情况的结果。准确的病理诊断至关重要。
