Doyle F H, Banks L M, Pennock J M
Arthritis Rheum. 1980 Oct;23(10):1205-14. doi: 10.1002/art.1780231019.
The diagnosis of Paget's disease of bone at its earliest osteolytic phase is difficult and requires radiographs of the highest quality. Calcitonin controls the bone resorption of uncomplicated Paget's disease but does not prevent disuse osteoporosis in normal and pagetic bones. Cessation of treatment leads to a recurrence of the osteolytic phase of the disease in some patients. Retreatment with human calcitonin arrests the bone resorption and permits bony consolidation of resorption clefts.
骨Paget病在其最早的溶骨期诊断困难，需要高质量的X线片。降钙素可控制单纯性Paget病的骨吸收，但不能预防正常骨和Paget病骨的废用性骨质疏松。在一些患者中，停止治疗会导致疾病溶骨期复发。用人降钙素再次治疗可抑制骨吸收，并使吸收间隙发生骨的巩固。
