酮咯酸与双氯芬酸治疗肾绞痛的比较。

Comparison of ketorolac and diclofenac in the treatment of renal colic.

作者信息

Cohen E, Hafner R, Rotenberg Z, Fadilla M, Garty M

机构信息

Internal Medicine F Department, Rabin Medical Center, Beilinson Campus, Petach-Tikva, Israel.

出版信息

Eur J Clin Pharmacol. 1998 Aug;54(6):455-8. doi: 10.1007/s002280050492.

DOI:10.1007/s002280050492

PMID:9776434

Abstract

OBJECTIVE

To compare the efficacy and adverse effects of ketorolac and diclofenac in the treatment of renal colic.

METHODS

In a double-blind, randomized clinical trial, 57 patients admitted to the emergency room for renal colic, received either 30 mg of ketorolac or 75 mg of diclofenac i.m. (intramuscularly). Evaluations were performed at 1, 2 h and 6 h after treatment. Pain was assessed by a four-point verbal rating scale (VRS) and a visual analogue scale (VAS). Only patients with at least moderate pain according to the VRS were included. Seventy-five milligrams of pethidine i.m. was given as rescue medicine, if insufficient analgesia was achieved. The adverse effects recorded were sedation, nausea and vomiting.

RESULTS

There was no significant difference between ketorolac and diclofenac, with respect to pain level over time, the number of patients requiring rescue medicine, or the level of adverse effects.

CONCLUSION

Ketorolac and diclofenac are equally effective in the treatment of renal colic.

摘要

目的

比较酮咯酸和双氯芬酸治疗肾绞痛的疗效及不良反应。

方法

在一项双盲随机临床试验中，57名因肾绞痛入住急诊室的患者，分别接受30毫克酮咯酸或75毫克双氯芬酸肌肉注射治疗。在治疗后1小时、2小时和6小时进行评估。采用四点口述分级量表（VRS）和视觉模拟量表（VAS）评估疼痛程度。仅纳入根据VRS至少为中度疼痛的患者。若镇痛效果不佳，给予75毫克哌替啶肌肉注射作为急救药物。记录的不良反应包括镇静、恶心和呕吐。