瑞典老年人群中的CYP2D6和CYP2C19基因分型

CYP2D6 and CYP2C19 genotypes in an elderly Swedish population.

作者信息

Yamada H, Dahl M L, Lannfelt L, Viitanen M, Winblad B, Sjöqvist F

机构信息

Department of Medical Laboratory Sciences and Technology Huddinge University Hospital, Sweden.

出版信息

Eur J Clin Pharmacol. 1998 Aug;54(6):479-81. doi: 10.1007/s002280050497.

DOI:10.1007/s002280050497

PMID:9776439

Abstract

OBJECTIVE

Eighty-three healthy elderly Swedish subjects (age 87 +/- 4 years, mean +/- SD, range 80-98 years) were genotyped with respect to the two genetic polymorphisms of oxidative drug metabolism, CYP2D6 and CYP2C19, using allele-specific polymerase chain reaction (PCR). A control population consisted of 248 younger unrelated healthy volunteers (age 31 +/- 9 years, range 19-63 years) for CYP2D6, and 162 (age 30 +/- 8 years, range 19-55 years) for CYP2C19.

RESULTS

No significant differences were found between the control groups and the elderly subjects with respect to the frequencies of the defect alleles CYP2D63, CYP2D64, CYP2C192 and CYP2C193. Neither were there any differences in the genotype frequencies, or the predicted phenotype frequencies. The study indicates that the CYP2D6 and CYP2C19 genotypes play no major role in the probability of reaching high age.

CONCLUSION

No genetically determined differences in the pharmacokinetics of drugs metabolized by these two polymorphic enzymes are to be expected in the oldest age groups compared with younger adults.

摘要

目的

采用等位基因特异性聚合酶链反应（PCR），对83名健康的瑞典老年受试者（年龄87±4岁，均值±标准差，范围80 - 98岁）进行氧化药物代谢的两种基因多态性，即CYP2D6和CYP2C19的基因分型。对照组包括248名年龄较小的无亲缘关系的健康志愿者（CYP2D6检测时年龄31±9岁，范围19 - 63岁），以及162名（CYP2C19检测时年龄30±8岁，范围19 - 55岁）。