Ema M, Miyawaki E, Kawashima K
National Institute of Health Sciences, Osaka Branch, Japan.
Toxicol Lett. 1998 Sep 1;98(1-2):87-93. doi: 10.1016/s0378-4274(98)00107-6.
The objective of this study was to further evaluate the developmental toxicity of di-n-butyl phthalate (DBP) administered during the second half of pregnancy. Pregnant rats were fed a diet containing DBP at a dose of 0 (control), 0.5, 1.0 or 2.0% ad libitum on days 11-21 of pregnancy. Average daily intakes of DBP were 331, 555 and 661 mg/kg for the 0.5, 1.0 and 2.0% groups, respectively. No significant changes induced by DBP were detected in the incidence of postimplantation loss and numbers of live fetuses and of resorptions and dead fetuses. The weights of male and female fetuses at 2.0% DBP were significantly decreased. The incidences of fetuses with cleft palate and fetuses with fusion of the sternebrae at 2.0% DBP and fetuses with undescended testes at 1.0 and 2.0% DBP were significantly increased. There were significant decreases in the anogenital distance (AGD) of male fetuses in the 1.0 and 2.0% DBP groups, also. AGD of female fetuses in the DBP-treated groups was comparable to that in the control group. It was concluded that DBP administered during the second half of pregnancy produced adverse effects on the reproductive development in male fetuses.
本研究的目的是进一步评估妊娠后半期给予邻苯二甲酸二丁酯（DBP）的发育毒性。在妊娠第11 - 21天，给怀孕大鼠随意喂食含0（对照）、0.5%、1.0%或2.0% DBP的饮食。0.5%、1.0%和2.0%组的DBP平均每日摄入量分别为331、555和661 mg/kg。在着床后丢失率、活胎数量、吸收胎和死胎数量方面，未检测到DBP引起的显著变化。2.0% DBP组的雄性和雌性胎儿体重显著降低。2.0% DBP组腭裂胎儿、胸骨融合胎儿的发生率以及1.0%和2.0% DBP组隐睾胎儿的发生率显著增加。1.0%和2.0% DBP组雄性胎儿的肛殖距（AGD）也显著缩短。DBP处理组雌性胎儿的AGD与对照组相当。得出的结论是，妊娠后半期给予DBP对雄性胎儿的生殖发育产生了不良影响。
