Ema M, Amano H, Itami T, Kawasaki H
National Institute of Hygienic Sciences, Osaka Branch, Japan.
Toxicol Lett. 1993 Aug;69(2):197-203. doi: 10.1016/0378-4274(93)90104-6.
Pregnant rats were given di-n-butyl phthalate (DBP) by gastric intubation at a dose of 0, 0.5, 0.63, 0.75 or 1.0 g/kg on days 7-15 of pregnancy. A significant decrease in the maternal body weight gain after treatment with DBP was found at a dose of 0.63 g/kg and above. Maternal death and complete resorption of implanted embryos in all the surviving dams were observed in the 1.0 g/kg group. Significantly increased incidence of postimplantation loss and decreased fetal weight were detected at doses of 0.63 and 0.75 g/kg. The incidence of fetuses with malformations was higher in the 0.63 and 0.75 g/kg groups than in the control group, and the difference was significant in the 0.75 g/kg group. Cleft palate were predominantly observed.
在妊娠第7至15天，通过胃管给怀孕大鼠灌胃邻苯二甲酸二正丁酯（DBP），剂量分别为0、0.5、0.63、0.75或1.0 g/kg。在剂量为0.63 g/kg及以上时，发现用DBP处理后母体体重增加显著减少。在1.0 g/kg组中，观察到所有存活母鼠出现母体死亡和植入胚胎完全吸收的情况。在0.63和0.75 g/kg剂量下，检测到着床后损失发生率显著增加，胎儿体重下降。0.63和0.75 g/kg组中畸形胎儿的发生率高于对照组，在0.75 g/kg组中差异显著。主要观察到腭裂。
