Siegert C E, Daha M R
Department of Nephrology, Leiden University Medical Center, The Netherlands.
Immunobiology. 1998 Aug;199(2):295-302. doi: 10.1016/s0171-2985(98)80034-x.
The observation of anti-C1q antibodies (C1qAb) in patients with various autoimmune diseases has led to the establishment of a strong correlation between these antibodies and renal involvement in patients with systemic lupus erythematosus (SLE). The measurement of anti C1q antibodies requires detailed insight in the reactivity of C1q with immune complexes and the methods to detect C1q as an antigen by solid phase assays. In this overview we describe the pitfulls of the anti C1qAb assay and its use in the measurement of C1qAb. Further we discuss the relevance of C1qAb in the pathogenesis of SLE and especially in relation to lupus nephritis.
在各种自身免疫性疾病患者中观察到抗C1q抗体（C1qAb），这使得人们确立了这些抗体与系统性红斑狼疮（SLE）患者肾脏受累之间的紧密关联。抗C1q抗体的检测需要深入了解C1q与免疫复合物的反应性以及通过固相分析将C1q作为抗原进行检测的方法。在本综述中，我们描述了抗C1qAb检测的陷阱及其在C1qAb测量中的应用。此外，我们还讨论了C1qAb在SLE发病机制中的相关性，特别是与狼疮性肾炎的关系。
