Chandy T, Sharma C P
Division of Biosurface Technology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojapura, Trivandrum, India.
J Biomater Appl. 1998 Oct;13(2):128-57. doi: 10.1177/088532829801300204.
Activated charcoal, long known to the ancients as a substance of therapeutic value in a variety of maladies, has recently been "rediscovered" to be of great value in medical applications. Activated charcoal hemoperfusion is effective in blood purification for removal of various circulating toxic materials and waste metabolites, directly. However, particulate release and platelet adhesion prevent its continued clinical use. Polymeric coatings or microencapsulation of charcoal within polymers have improved their blood compatibility. Chitosan encapsulated activated charcoal (ACCB) beads have been extensively investigated in our group for the removal of various toxins such as urea, creatinine, uric acid, bilirubin, etc. This article highlights various methods of microencapsulation procedures of activated charcoal and the importance of this novel material for a variety of biomedical applications. Further, this review provides an insight to the future perspectives for using them in clinical practice.
活性炭，古人早就知道它是一种对多种疾病具有治疗价值的物质，最近又“重新被发现”在医学应用中具有巨大价值。活性炭血液灌流在血液净化中可直接有效去除各种循环中的有毒物质和废物代谢产物。然而，颗粒释放和血小板黏附阻碍了其在临床上的持续应用。聚合物涂层或在聚合物内对活性炭进行微囊化改善了它们的血液相容性。壳聚糖包裹的活性炭（ACCB）珠已在我们小组中得到广泛研究，用于去除各种毒素，如尿素、肌酐、尿酸、胆红素等。本文重点介绍了活性炭微囊化的各种方法以及这种新型材料在各种生物医学应用中的重要性。此外，本综述还提供了对其在临床实践中应用的未来前景的见解。
