Zakzanis K K
York University, Department of Psychology, Toronto, Canada.
J Clin Exp Neuropsychol. 1998 Apr;20(2):259-69. doi: 10.1076/jcen.20.2.259.1174.
Meta-analytic methods were used to determine the sensitivity of neuropsychological, structural, and physiological measures to temporal-hippocampal system function in dementia of the Alzheimer's type. Effect sizes are reported for the California Verbal Learning Test, the Wechsler Memory Scale-Revised, structural (i.e., magnetic resonance imaging [MRI]), and functional (i.e., positron emission tomography [PET], single photon emission computed tomography [SPECT]) neuroimaging methods. Overall, effect sizes from MRI studies are larger than those obtained from SPECT and PET, respectively, but not as large as those obtained from the neuropsychological measures. On the basis of this finding, the neuropsychological and gross pathologic similarities between Alzheimer's disease, other dementing conditions, and mixed dementias, warrants the coupling of neuropsychological evaluation for its sensitivity with neuroimaging visualization for its specificity in improving diagnostic and differential accuracy.
采用荟萃分析方法来确定神经心理学、结构和生理测量对阿尔茨海默病型痴呆中颞叶 - 海马系统功能的敏感性。报告了加利福尼亚言语学习测验、韦氏记忆量表修订版、结构（即磁共振成像[MRI]）和功能（即正电子发射断层扫描[PET]、单光子发射计算机断层扫描[SPECT]）神经成像方法的效应大小。总体而言，MRI研究的效应大小分别大于SPECT和PET的效应大小，但不如神经心理学测量获得的效应大小大。基于这一发现，阿尔茨海默病、其他痴呆病症和混合性痴呆之间的神经心理学和大体病理学相似性，使得将具有敏感性的神经心理学评估与具有特异性的神经成像可视化相结合，对于提高诊断和鉴别准确性是必要的。
