宫颈细胞学涂片中非典型意义不明确腺细胞的重要性。
Importance of atypical glandular cells of uncertain significance in cervical cytologic smears.
作者信息
Korn A P, Judson P L, Zaloudek C J
机构信息
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, USA.
出版信息
J Reprod Med. 1998 Sep;43(9):774-8.
OBJECTIVE
To determine the clinical implications of atypical glandular cells of uncertain significance (AGCUS) in cervical cytologic smears.
STUDY DESIGN
Retrospective analysis.
RESULTS
Eighty-eight of 32,181 (0.27%) cervical smears obtained during the study period contained AGCUS. Of the 47 women with AGCUS, 16 had intraepithelial or invasive neoplasms (34%; 95% confidence interval, 21-49%), including 9 low or high grade squamous intraepithelial lesions, 1 adenocarcinoma in situ of the cervix, 3 adenocarcinomas of the cervix, 2 adenocarcinomas of the endometrium and 1 adenoid basal cell carcinoma of the cervix.
CONCLUSION
The high prevalence of cervical and endometrial neoplasia among women with the isolated finding of AGCUS on cervical cytologic smears warrants a thorough diagnostic evaluation.
目的
确定宫颈细胞学涂片检查中意义不明确的非典型腺细胞（AGCUS）的临床意义。
研究设计
回顾性分析。
结果
在研究期间获取的32181份宫颈涂片样本中，有88份（0.27%）含有AGCUS。在47例AGCUS患者中，16例患有上皮内或浸润性肿瘤（34%；95%置信区间为21 - 49%），包括9例低级别或高级别鳞状上皮内病变、1例宫颈原位腺癌、3例宫颈腺癌、2例子宫内膜腺癌和1例宫颈腺样基底细胞癌。
结论
宫颈细胞学涂片检查仅发现AGCUS的女性中，宫颈和子宫内膜肿瘤的高患病率需要进行全面的诊断评估。
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