Kay A B, Smith A F, McGavin C R, Tuft S B
J Clin Pathol. 1976 Oct;29(10):887-9. doi: 10.1136/jcp.29.10.887.
Levels of IgG, IgA, IgM, the total haemolytic complement (CH50), and the individual components C1q, C3, C4, C6, and C7 were measured in 29 pleural effusions. Of these, 18 were associated with carcinoma of the bronchus and 11 were non-malignant effusions including empyemas. The level of IgG was significantly lower in the malignant group when compared with non-malignant effusions. The usefulness of measurements of IgG with respect to malignant effusions associated with carcinoma of the bronchus requires an expanded study to show whether it has any real diagnostic value. There were no significant differences in other immunoglobulins, the CH50, and individual complement components between the two groups. The identification of total haemolytic activity in the majority of effusions in both groups indicates that all nine components of the classical pathway of complement, including macromolecules such as C1, can be present in pleural fluids.
对29例胸腔积液患者检测了IgG、IgA、IgM、总溶血补体（CH50）以及补体单个成分C1q、C3、C4、C6和C7的水平。其中，18例与支气管癌相关，11例为非恶性积液，包括脓胸。与非恶性积液相比，恶性组的IgG水平显著降低。对于与支气管癌相关的恶性积液，检测IgG的效用需要进一步扩大研究，以确定其是否具有实际诊断价值。两组之间其他免疫球蛋白、CH50和补体单个成分无显著差异。两组中大多数积液都具有总溶血活性，这表明补体经典途径的所有九个成分，包括C1等大分子，都可能存在于胸液中。
