Couch S C, Philipson E H, Bendel R B, Wijendran V, Lammi-Keefe C J
Department of Nutritional Sciences, University of Connecticut, Storrs 06269, USA.
J Reprod Med. 1998 Sep;43(9):816-22.
To describe lipid and lipoprotein perturbations in gestational diabetes mellitus (GDM) and to examine the potential consequences--e.g, increased birth weight and increased placental lipid transfer.
Maternal and cord free fatty acids (FFAs) and total, very low density lipoprotein (VLDL), low density lipoprotein (LDL), high density lipoprotein (HDL) (and maternal HDL2 and HDL3), triglyceride (TG), and cholesterol and dietary intake were determined for women with diet-treated GDM and for healthy pregnant women with normal glucose tolerance.
Women with GDM had higher hemoglobin A1c than controls, while body weight gain was significantly lower for women with GDM as compared to controls. Plasma and lipoprotein TG concentrations were greater for women with GDM, and although plasma FFAs were higher in women with GDM versus controls, the difference was not significant. No differences were observed between groups with respect to maternal plasma or lipoprotein cholesterol. Cord plasma and lipoprotein lipids were similar between groups; with the exception of VLDL + LDL TG, which was lower in women with GDM. In controls, there were significant correlations between maternal plasma TG and cord FFAs; maternal HDL2 cholesterol and cord plasma cholesterol; and maternal plasma TG, maternal HDL2 cholesterol, cord FFAs, and infant birth weight. In GDM, maternal plasma cholesterol and cord VLDL + LDL cholesterol correlated. There were no significant correlations between maternal or cord lipids and infant birth weight in women with GDM.
Hypertriglyceridemia, rather than hypercholesterolemia, is a feature of GDM. However, elevations in maternal plasma and lipoprotein TGs in women with GDM were not related to fetal lipid concentrations or infant birth weight.
描述妊娠期糖尿病（GDM）患者的脂质和脂蛋白紊乱情况，并研究其潜在后果，如出生体重增加和胎盘脂质转运增加。
测定饮食治疗的GDM女性和糖耐量正常的健康孕妇的母体和脐带游离脂肪酸（FFA）、总脂质、极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）（以及母体HDL2和HDL3）、甘油三酯（TG）、胆固醇和饮食摄入量。
GDM女性的糖化血红蛋白A1c高于对照组，而GDM女性的体重增加显著低于对照组。GDM女性的血浆和脂蛋白TG浓度更高，尽管GDM女性的血浆FFA高于对照组，但差异不显著。两组间母体血浆或脂蛋白胆固醇无差异。两组间脐带血浆和脂蛋白脂质相似；GDM女性的VLDL + LDL TG除外，其较低。在对照组中，母体血浆TG与脐带FFA、母体HDL2胆固醇与脐带血浆胆固醇、母体血浆TG、母体HDL2胆固醇、脐带FFA与婴儿出生体重之间存在显著相关性。在GDM中，母体血浆胆固醇与脐带VLDL + LDL胆固醇相关。GDM女性的母体或脐带脂质与婴儿出生体重之间无显著相关性。
高甘油三酯血症而非高胆固醇血症是GDM的一个特征。然而，GDM女性母体血浆和脂蛋白TG的升高与胎儿脂质浓度或婴儿出生体重无关。
