University of Health Sciences Turkey, Ankara Etlik Zubeyde Hanım Women's Health and Research Center Turkey, Department of Obstetrics and Gynecology - Ankara, Turkey.
Rev Assoc Med Bras (1992). 2024 Aug 16;70(8):e20231111. doi: 10.1590/1806-9282.20231111. eCollection 2024.
Subfatin, a newly discovered adipokine, plays a pivotal role in the regulation of glucose metabolism. The relationship between gestational diabetes mellitus and maternal dyslipidemia is well-documented.
This study aims to assess serum subfatin levels and the triglyceride/high-density lipoprotein cholesterol ratio in women with one abnormal glucose tolerance test value and those with gestational diabetes mellitus.
In this case-control study, 105 pregnant women were categorized into three groups: women with normal 3-h oral glucose tolerance test results (n=35), women with one abnormal 3-h oral glucose tolerance test result (n=35), and women diagnosed with gestational diabetes mellitus (n=35). Serum subfatin levels were measured using human enzyme-linked immunosorbent assay kits.
Serum subfatin levels were significantly lower in the gestational diabetes mellitus group (0.94±0.15 ng/mL) compared to the normal oral glucose tolerance test group (1.48±0.55 ng/mL) and the group with one abnormal oral glucose tolerance test result (1.50±0.59 ng/mL). The triglyceride/high-density lipoprotein cholesterol ratio was also lower in the healthy control group than in the gestational diabetes mellitus and one abnormal oral glucose tolerance test result groups.
Serum subfatin levels in women with one abnormal abnormal glucose tolerance test value are compared to those in the control group, while the triglyceride/high-density lipoprotein cholesterol ratio is significantly altered in women with one abnormal abnormal glucose tolerance test value when compared to the control group.
新近发现的脂肪因子——亚精胺，在调节葡萄糖代谢方面发挥着关键作用。妊娠糖尿病与母体血脂异常的关系已有大量文献报道。
本研究旨在评估糖耐量试验值异常的孕妇和妊娠糖尿病孕妇的血清亚精胺水平及甘油三酯/高密度脂蛋白胆固醇比值。
采用病例对照研究，将 105 例孕妇分为三组：糖耐量试验 3 小时结果正常组（n=35）、糖耐量试验 1 小时异常组（n=35）和妊娠糖尿病组（n=35）。采用酶联免疫吸附试验检测血清亚精胺水平。
与糖耐量试验正常组（1.48±0.55ng/mL）和糖耐量试验 1 小时异常组（1.50±0.59ng/mL）相比，妊娠糖尿病组血清亚精胺水平显著降低（0.94±0.15ng/mL）。与健康对照组相比，妊娠糖尿病组和糖耐量试验 1 小时异常组的甘油三酯/高密度脂蛋白胆固醇比值均较低。
与健康对照组相比，糖耐量试验值异常的孕妇血清亚精胺水平较低，而与健康对照组相比，糖耐量试验值异常的孕妇甘油三酯/高密度脂蛋白胆固醇比值显著改变。
