Duvic M, Asano A T, Hager C, Mays S
MD Anderson Cancer Center, and Department of Dermatology, University of Texas Medical School, Houston 77030, USA.
J Am Acad Dermatol. 1998 Oct;39(4 Pt 2):S129-33. doi: 10.1016/s0190-9622(98)70309-3.
The 3 major features of psoriasis--abnormal differentiation of keratinocytes, hyperproliferation of keratinocytes, and infiltration of inflammatory components into the skin--can be quantified by measuring levels of certain biochemical markers. Psoriasis is associated with upregulation or downregulation of several of these markers. Tazarotene helps to normalize the levels of the markers, thereby bringing about clinical improvement.
银屑病的三大主要特征——角质形成细胞异常分化、角质形成细胞过度增殖以及炎症成分浸润皮肤——可以通过测量某些生化标志物的水平来量化。银屑病与其中几种标志物的上调或下调有关。他扎罗汀有助于使这些标志物的水平正常化，从而带来临床改善。
