C3H/He小鼠的自发性自身免疫性胃炎：一种新的胃自身免疫小鼠模型。
Spontaneous autoimmune gastritis in C3H/He mice: a new mouse model for gastric autoimmunity.
作者信息
Alderuccio F, Toh B H
机构信息
Department of Pathology and Immunology, Monash University Medical School, Prahran, Victoria, Australia.
出版信息
Am J Pathol. 1998 Oct;153(4):1311-8. doi: 10.1016/S0002-9440(10)65676-3.
Autoimmune gastritis is the underlying pathological lesion of pernicious anemia in humans. The lesion is characterized by a chronic inflammatory infiltrate in the gastric mucosa with loss of parietal and zymogenic cells. It is associated with circulating autoantibodies to the gastric H/K-ATPase, the enzyme responsible for acidification of gastric juice. Experimental models of autoimmune gastritis have previously been produced in mice after a variety of manipulations, including thymectomy. Here we report for the first time a spontaneous mouse model of autoimmune gastritis in C3H/He mice. The spontaneous gastritis is also accompanied by circulating autoantibodies to the gastric H/K-ATPase. The spontaneous mouse model should be useful for studies directed toward the immunopathogenesis and treatment of autoimmune gastritis.
自身免疫性胃炎是人类恶性贫血的潜在病理病变。该病变的特征是胃黏膜出现慢性炎症浸润，伴有壁细胞和主细胞丧失。它与针对胃H/K-ATP酶（负责胃酸分泌的酶）的循环自身抗体有关。此前，通过包括胸腺切除在内的各种操作，已在小鼠中建立了自身免疫性胃炎的实验模型。在此，我们首次报道了C3H/He小鼠中的一种自身免疫性胃炎自发小鼠模型。这种自发性胃炎也伴有针对胃H/K-ATP酶的循环自身抗体。该自发小鼠模型应有助于针对自身免疫性胃炎的免疫发病机制和治疗的研究。
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