激酶-磷酸酶竞争调节枯草芽孢杆菌的发育。

Kinase-phosphatase competition regulates Bacillus subtilis development.

作者信息

Perego M

机构信息

Dept of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA.

出版信息

Trends Microbiol. 1998 Sep;6(9):366-70. doi: 10.1016/s0966-842x(98)01350-x.

DOI:10.1016/s0966-842x(98)01350-x

PMID:9778730

Abstract

The major regulator of sporulation initiation in Bacillus subtilis is the phosphorelay, a multicomponent signal transduction system. A myriad of signals, both positive and negative, from the environment, cell cycle and metabolism is received and interpreted by the phosphorelay and integrated through the opposing activity of protein kinases and protein aspartate phosphatases to create an extremely sophisticated regulatory network.

摘要

枯草芽孢杆菌中孢子形成起始的主要调节因子是磷酸化信号转导途径，这是一种多组分信号转导系统。磷酸化信号转导途径接收来自环境、细胞周期和代谢的无数正负信号，并对其进行解读，通过蛋白激酶和天冬氨酸蛋白磷酸酶的相反活性进行整合，从而形成一个极其复杂的调控网络。